Super CitriMax supplement for weight loss
Garcinia Cambogia CitriMax HCA-600 SXS (standardized to
contain 60% hydroxycitric acid) Hydroxycitric acid is derived from the Malabar
tamarind tropical fruit (Garcinia cambogia) native to India. Hydroxycitric acid
has been found to inhibit mitochondrial citrate lyase, leading to decreased
acetyl coenzyme A production and decreased fatty acid synthesis. CitriMax is a
high quality trademark extract of garcinia cambogia. No human studies with
Citrimax were found as of December 2008.
CitriMax is found in an effective, natural weight management product called Diet Rx formulated by a medical doctor.
CitriMax appears to be safe with no major side effects
InterHealth Nutraceuticalsí patented calcium / potassium (-)hydroxycitric acid weight management ingredient, was shown to have no toxic effects in a two-generation reproduction study. The results, published in the June 2008 issue of Toxicology Mechanisms and Methods, further affirms the long-term safety of the popular diet ingredient. The study evaluated the effects of Super CitriMax on the reproductive systems of male and female rats, specifically the post-natal maturation and reproductive capacity of their offspring, and possible cumulative effects through multiple generations. Animalsí diets were supplemented with varying doses of Super CitriMax equivalent to 1018 and 1524 mg/kg body weight a day in male and female rats, respectively. Both parents and offspring were examined daily and a variety of reproductive parameters were assessed. Upon conclusion of the study, the reproductive systems and performance of animals receiving Super CitriMax were no different than those of healthy controls. Parameters evaluated included sexual maturity, fertility and mating, gestation, giving birth, litter properties, lactation and development of offspring. In a subsequent next-generation, follow-up study, offspring of the first study were given up to 1524 mg per kg of body weight of Super CitriMax. There was no evidence of maternal or fetal toxicity in their offspring as well.
Super CitriMax research
Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats.
Mol Cell Biochem. 2007. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF.
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX.
Super CitriMax (HCA-SX) is a novel calcium / potassium salt of (-)-hydroxycitric acid extracted from the dried fruit rind of the plant Garcinia cambogia, and commonly consumed as weight loss dietary supplement. In the present study, we investigated the effect of HCA-SX on inflammation, oxidative stress and insulin resistance in developing obese Zucker rats, an animal model of type II diabetes associated with inflammation and oxidative stress. Male Zucker rats (5-week old) were supplemented with vehicle (control) and HCA-SX in drinking water for 7 weeks... These results suggest that HCA-SX supplementation in obese Zucker rats reduces food-intake, body weight gain, and also attenuates the increases in inflammation, oxidative stress, and insulin resistance observed in untreated animals. Therefore, HCA-SX may be used as an intervention to overcome obesity-related complications, including inflammation, oxidative stress, and insulin resistance.
Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric
acid in weight control.
Int J Clin Pharmacol Res. 2005. Preuss HG, Garis RI, Bramble JD, Bagchi D, Bagchi M, Rao CV, Satyanarayana S. Department of Physiology and Biophysics, Georgetown University Medical Center, Basic Science Building, N.W., Washington, DC, USA.
The weight-loss efficacy of a novel, water-soluble, calcium-potassium salt of (-)-hydroxycitric acid (HCA-SX) was re-examined in 90 obese subjects (BMI: 30-50.8 kg/m2). We combined data from two previously reported randomized, double-blind, placebo-controlled clinical studies in order to achieve a better statistical evaluation based on a larger population. This re-examination of data also allowed us to reflect more intensely on various aspects of weight loss studies. Subjects were randomly divided into three groups: group A received a daily dose of HCA-SX 4, 667 mg (providing 2,800 mg HCA per day); group B was given a daily dose of a combination of HCA-SX 4,667 mg, niacin-bound chromium (NBC) 4 mg (providing 400 microg elemental chromium), and Gymnema sylvestre extract (GSE) 400 mg (providing 100 mg gymnemic acid); and group C received a placebo in three equally divided doses 30-60 min before each meal. We conclude that dosage levels, timing of administration, subject compliance and bioavailability of HCA-SX significantly affect results and that when taken as directed, HCA-SX is a highly effective adjunct to healthy weight control.