Conjugated linoleic acid CLA is a slightly altered form of the essential fatty acid linoleic acid and is promoted for weight loss. Some studies, mostly in rodents, have shown that it may reduce weight but others have shown conflicting results. It's possible that Conjugated linoleic acid could be effective as a weight loss supplement but I'm not yet totally convinced. Overall, there does not seem to be convincing evidence that Conjugated linoleic acid is clearly helpful as a weight loss supplement. However some people do like to use Conjugated linoleic acid. We think Diet Rx, which has a combination of hoodia extract, green tea extract, ginger, cinnamon, garcinia cambogia, choline, carnitine, 5-HTP, guggul, acetylcarnitine, and several other herbs and nutrients is a better option for appetite suppression than Conjugated linoleic acid alone. You can find out more about Diet Rx below.
Conjugated linoleic acid supplement, 750 mg, 50 softgels
Conjugated linoleic acid (conjugated linoleic acid) is a recently recognized supplement. Conjugated linoleic acid is found naturally in a variety of foods, including dairy. Conjugated linoleic acid offers a rich source of conjugated linoleic acid to supplement the diet naturally.
Each capsule provides 750 mg Conjugated linoleic acid supplement.
Directions: Take 1, 2 or 3 Conjugated linoleic acid softgels daily or as recommended by your health care provider.
Click here to buy a Conjugated linoleic acid supplement, get a FREE bottle of Diet Rx
Diet Rx for appetite
If you would like to eat less, consider a product called Diet Rx. This natural appetite suppressant works without stimulants. Diet Rx does not have Conjugated linoleic acid and has no added caffeine, ephedra, ephedrine alkaloids, synephrine, hormones, guarana, ginseng, or stimulating amino acids.
More about these fatty acids
Conjugated linoleic acid is a family of positional and geometric isomers with 2 conjugated double bonds formed from linoleic acid and linolenic acid. Most dietary Conjugated linoleic acid in humans is obtained from dairy products, accounting for the cis-9,trans-11 Conjugated linoleic acid isomer, also known as rumenic acid, for more than 90% of the total Conjugated linoleic acid intake. Commercial Conjugated linoleic acid supplements industrially produced, contain trans-10,cis-12 and cis-9,trans-11 Conjugated linoleic acid isomers in diverse proportions. Different companies making Conjugated linoleic acid supplements may have slightly or moderately different fatty acid compositions.
A 2004 study showed that Conjugated linoleic acid had beneficial effects on cholesterol metabolism, it had unfavorable effects on blood sugar and insulin sensitivity. Dairy products naturally enriched with cis-9,trans-11 Conjugated linoleic acid and trans-11 18:1 do not appear to have a significant effect on blood lipid profile.
Data from 18 previous studies on Conjugated linoleic acid were analyzed. It was found that, when given at a dose of 3 grams per day, Conjugated linoleic acid appeared moderately effective at promoting body fat loss. People who took a Conjugated linoleic acid supplement lost a modest amount of 0.2 pounds of fat per week compared to placebo. Dr. Leah D. Whigham, of the University of Wisconsin at Madison, found the body-fat benefits of Conjugated linoleic acid accrued for 6 months, then gradually faded. It is not clear how Conjugated linoleic acid works, but it may affect enzymes responsible for body fat storage. There have been some concerns raised about the side effects of consuming Conjugated linoleic acid. Some studies, for instance, have suggested that the fat may promote insulin resistance, a precursor to diabetes. But other studies have either failed to show this effect, or found that Conjugated linoleic acid improves the body's use of insulin. American Journal of Clinical Nutrition, May 2007.
Weight loss 2006 study
Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain
American Journal of Clinical Nutrition 2006
Conjugated linoleic acid ( Conjugated linoleic acid ) is marketed as a safe, simple, and effective dietary supplement to promote the loss of body fat and weight. However, most previous studies have been of short duration and inconclusive, and some recent studies have questioned the safety of long-term supplementation with Conjugated linoleic acid. Our aim was to assess the effect of 1 year supplementation with Conjugated linoleic acid (3.4 grams per day) on body weight and body fat regain in moderately obese people. One hundred twenty-two obese healthy subjects with a body mass index (in kg/m2) > 28 underwent an 8-wk dietary run-in with energy restriction (3300–4200 kJ/d). One hundred one subjects who lost >8% of their initial body weight were subsequently randomly assigned to a 1-y double-blind Conjugated linoleic acid (3.4 g/d) or placebo (olive oil) supplementation regime in combination with a modest hypocaloric diet of –1250 kJ/d. After 1 year, no significant difference in body weight or body fat regain was observed between the treatments. The Conjugated linoleic acid group regained a mean 4.0 kg body weight and 2 kg fat mass compared with a regain of 4 kg body weight and 2.7 kg fat mass in the placebo group. No significant differences in reported adverse effects or indexes of insulin resistance were observed, but a significant increase in the number of leukocytes was observed with Conjugated linoleic acid supplementation. A 3.4-g daily for 1 year does not prevent weight or fat mass regain in a healthy obese population.
Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men
American Journal of Clinical Nutrition 2005
The researchers compared the effects on plasma lipoproteins and body composition of the consumption of a modified butter naturally enriched with Conjugated linoleic acid (Conjugated linoleic acid-B: 4.22 g Conjugated linoleic acid/100 g butter fat) by the addition of sunflower oil to the diet of dairy cows with the consumption of a control butter (CON-B) that was low in Conjugated linoleic acid (0.38 g Conjugated linoleic acid/100 g butter fat). The study was a crossover design study including an 8-wk washout period, 16 men were fed each of the 2 experimental isoenergetic diets, providing 15% of energy as protein, 45% as carbohydrates, and 40% as lipids, of which >60% was derived from experimental fats, for 4 wk. Consumption of the Conjugated linoleic acid-B diet induced a significantly smaller reduction in plasma total cholesterol and in the ratio of total to HDL cholesterol than did consumption of the CON-B diet. Abdominal adipose tissue area showed no difference in accumulation of either visceral or subcutaneous adipose tissue after the 2 experimental diets. These results suggest that a 10-fold Conjugated linoleic acid enrichment of butter fat does not induce beneficial metabolic effects in overweight or obese men.
Conjugated linoleic acid
supplementation, insulin sensitivity, and lipoprotein metabolism in patients
with type 2 diabetes mellitus.
American Journal of Clinical Nutrition 2004
Some animal studies have suggested that conjugated linoleic acid Conjugated linoleic acid supplementation may have therapeutic potential with respect to insulin sensitivity and lipid metabolism, which are important cardiovascular disease (CVD) risk factors associated with type 2 diabetes mellitus. We investigated the effect of Conjugated linoleic acid supplementation on markers of glucose and insulin metabolism, lipoprotein metabolism, and inflammatory markers of CVD in subjects with type 2 diabetes. The study was a randomized, double-blind, placebo-controlled trial. Thirty-two subjects with stable, diet-controlled type 2 diabetes received Conjugated linoleic acid (3.0 g/d; 50:50 blend of cis-9,trans-11 Conjugated linoleic acid and trans-10,cis-12 Conjugated linoleic acid) or control for 8 wk. A 3-h 75-g oral-glucose-tolerance test was performed, and fasting plasma lipid concentrations and inflammatory markers were measured before and after the intervention. Conjugated linoleic acid supplementation significantly increased fasting glucose concentrations and reduced insulin sensitivity. Total HDL-cholesterol concentrations increased by 8%, which was due to a significant increase in HDL2-cholesterol concentrations. The ratio of LDL to HDL cholesterol was significantly reduced. Conjugated linoleic acid supplementation reduced fibrinogen concentrations but had no effect on the inflammatory markers of CVD (C-reactive protein and interleukin 6). Conjugated linoleic acid supplementation had an adverse effect on insulin and glucose metabolism. Whereas Conjugated linoleic acid had positive effects on HDL metabolism and fibrinogen, a therapeutic nutrient should not be associated with potentially adverse effects on other clinical markers of type 2 diabetes.
Conjugated linoleic acid supplementation for 1 y reduces body
fat mass in healthy overweight humans
Background: Short-term trials showed that conjugated linoleic acid Conjugated linoleic acid may reduce body fat mass (BFM) and increase lean body mass (LBM), but the long-term effect of Conjugated linoleic acid was not examined. Objective: The objective of the study was to ascertain the 1-y effect of Conjugated linoleic acid on body composition and safety in healthy overweight adults consuming an ad libitum diet. Design: Male and female volunteers (n = 180) with body mass indexes (in kg/m2) of 25–30 were included in a double-blind, placebo-controlled study. Subjects were randomly assigned to 3 groups: Conjugated linoleic acid free fatty acid (FFA), Conjugated linoleic acid triacylglycerol, or placebo (olive oil). Change in BFM, as measured by dual-energy X-ray absorptiometry, was the primary outcome. Secondary outcomes included the effects of Conjugated linoleic acid on LBM, adverse events, and safety variables. Results: Mean (± SD) BFM in the Conjugated linoleic acid triacylglycerol and Conjugated linoleic acid FFA groups was 8.7% and 6.9%, respectively, lower than that in the placebo group. Subjects receiving Conjugated linoleic acid FFA had 1.8 ± 4.3% greater LBM than did subjects receiving placebo. These changes were not associated with diet or exercise. LDL increased in the Conjugated linoleic acid FFA group, HDL decreased in the Conjugated linoleic acid triacylglycerol group, and lipoprotein(a) increased in both Conjugated linoleic acid groups compared with month 0. Fasting blood glucose concentrations remained unchanged in all 3 groups. Glycated hemoglobin rose in all groups from month 0 concentrations, but there was no significant difference between groups. Adverse events did not differ significantly between groups. Long-term supplementation with Conjugated linoleic acid FFA or Conjugated linoleic acid triacylglycerol reduces BFM in healthy overweight adults.
Conjugated linoleic acid content of human plasma.
Lipids Health Dis. 2008. Zlatanos SN, Laskaridis K, Sagredos A. Zlatanos SN, Laskaridis K, Sagredos A. Laboratory of Organic Chemistry, Chemical Engineering Dept,, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Conjugated linoleic acid (CLA), a naturally occurring anti carcinogen found in dairy products, is an intermediary product of ruminal biohydrogenation of polyunsaturated fatty acids. Few data exist on the Conjugated linoleic acid content of the human blood plasma. The determination of a "normal" content could help in estimating if a person consumes satisfactory amounts of Conjugated linoleic acid with the diet and thus takes advantage of its potential beneficial effects on health. The purpose of this study was to compare the plasma Conjugated linoleic acid content of individuals not consuming dairy products (group 1, n = 12), individuals consuming normal amounts of dairy products (group 2, n = 77) and individuals consuming Conjugated linoleic acid supplement (group 3, n = 12). The only Conjugated linoleic acid isomer that presented higher percentage than the detection limit (0.03% of total fatty acids) was rumenic acid (cis9, trans11-octadecadienoic acid). An interesting finding is that compared to the other two groups, group 3 members show the highest average plasma content in rumenic acid, i.e. 0.20% of total fatty acids. The present study could be characterized as the first step in the direction of establishing a normal Conjugated linoleic acid content of human plasma. Based on these results, it could be suggested that the lower limit of the plasma Conjugated linoleic acid content is approximately 0.1% of total fatty acids.
Q. Why not eat more foods that have Conjugated linoleic acid rather than taking a Conjugated linoleic acid supplement?
A. A liter of full-fat milk contains about 1 gram of Conjugated linoleic acid. This is not practical in terms of weight loss.
Q. Would taking a
Conjugated linoleic acid
supplement along with hoodia help with weight loss more effectively?
A. It's hard to say, but the combination could be safe to try.
Q. Can a Conjugated
linoleic acid supplement be
taken along with Diet Rx?
A. Probably, but since Diet Rx works so well to reduce appetite, there may not be a need to take a Conjugated linoleic acid supplement.
This Conjugated linoleic acid page was last updated in February 2009.
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