Conjugated linoleic acid CLA is a slightly altered form of the essential fatty acid linoleic acid.
Conjugated linoleic acid for weight loss
Some studies, mostly in rodents, have shown that
Conjugated linoleic acid
may reduce weight but others have shown conflicting results. It's possible that
Conjugated linoleic acid could be
effective as a weight loss supplement but I'm not yet totally convinced.
Overall, there does not seem to be convincing evidence that Conjugated
linoleic acid is clearly helpful as a
weight loss supplement. However some people do like to use Conjugated linoleic
acid.
We think Diet Rx,
which has a combination of hoodia extract, green
tea extract, ginger, cinnamon, garcinia cambogia, choline, carnitine, 5-HTP,
guggul, acetylcarnitine,
and several other herbs and nutrients
is a better option for appetite suppression than Conjugated linoleic
acid
alone. You can find out more about Diet Rx
below.
Conjugated linoleic acid supplement, 750 mg, 50 softgels - Club Natural
Conjugated
linoleic acid
(conjugated linoleic acid) is a recently recognized supplement.
Conjugated linoleic acid is found naturally in a variety of foods,
including dairy. Conjugated linoleic acid offers a rich source of
conjugated linoleic acid to supplement the diet naturally.
Each capsule provides 750 mg Conjugated linoleic acid supplement.
Directions: Take 1, 2 or 3 Conjugated linoleic acid softgels daily or as recommended by
your health care provider.
Diet Rx for appetite
suppression
If you would like to eat less, consider a product called Diet Rx. This natural
appetite suppressant works without stimulants. Diet Rx does not have Conjugated
linoleic acid and has no added caffeine, ephedra, ephedrine alkaloids, synephrine, hormones, guarana, ginseng, or
stimulating amino acids.
Benefits of Diet Rx
All
natural appetite suppressant, decreases appetite so you eat less
Helps you maintain healthy blood sugar levels
Helps you maintain healthy cholesterol and lipid levels
Provides a variety of antioxidant from two dozen herbs and nutrients
Provides healthy fiber
Improves energy
Balances mood
Improves mental concentration and focus
Improves will power and choice of food selection
More about Conjugated linoleic acid fatty
acids
Conjugated linoleic acid is a family
of positional and geometric isomers with 2 conjugated double bonds formed from
linoleic acid and linolenic acid. Most dietary Conjugated linoleic acid in humans is obtained from
dairy products, accounting for the cis-9,trans-11 Conjugated linoleic acid isomer, also known
as rumenic acid, for more than 90% of the total Conjugated linoleic acid intake. Commercial
Conjugated linoleic acid
supplements industrially produced, contain trans-10,cis-12 and
cis-9,trans-11 Conjugated linoleic acid isomers in diverse proportions. Different companies
making Conjugated linoleic acid supplements may have slightly or moderately different fatty
acid compositions.
Conjugated linoleic acid and cholesterol
An October 2004 study showed that Conjugated
linoleic acid had beneficial effects on
cholesterol metabolism, it had unfavorable effects on blood sugar and
insulin sensitivity. Dairy products naturally enriched with cis-9,trans-11
Conjugated linoleic acid and trans-11 18:1 do not appear to have a significant effect on blood
lipid profile.
Conjugated linoleic
acid and weight loss
2007
Data from 18 previous studies on Conjugated linoleic acid were analyzed. It was found
that, when given at a dose of 3 grams per day, Conjugated linoleic acid appeared moderately
effective at promoting body fat loss. People who took a Conjugated
linoleic acid supplement lost a modest
amount of 0.2 pounds of fat per week compared to placebo. Dr. Leah D.
Whigham, of the University of Wisconsin at Madison, found the body-fat
benefits of Conjugated linoleic acid accrued for 6 months, then gradually faded. It is not
clear how Conjugated linoleic acid works, but it may affect enzymes responsible for body fat
storage.
There have been some concerns raised about the side effects of consuming
Conjugated linoleic acid. Some studies, for instance, have suggested that the fat may promote
insulin resistance, a precursor to diabetes. But other studies have either
failed to show this effect, or found that Conjugated linoleic acid improves the body's use of
insulin. American Journal of Clinical Nutrition, May 2007.
Conjugated linoleic acid and weight loss 2006
Conjugated linoleic acid supplementation for 1 y does not
prevent weight or body fat regain
American Journal of Clinical Nutrition, Vol. 83, No. 3,
606-612, March 2006
Conjugated linoleic acid ( Conjugated linoleic acid ) is marketed as a safe, simple, and effective
dietary supplement to promote the loss of body fat and weight. However, most
previous studies have been of short duration and inconclusive, and some recent
studies have questioned the safety of long-term supplementation with Conjugated
linoleic acid. Our
aim was to assess the effect of 1 year supplementation with Conjugated linoleic
acid (3.4 grams per
day) on body weight and body fat regain in moderately obese people. One hundred
twenty-two obese healthy subjects with a body mass index (in kg/m2) > 28
underwent an 8-wk dietary run-in with energy restriction (3300–4200 kJ/d). One
hundred one subjects who lost >8% of their initial body weight were subsequently
randomly assigned to a 1-y double-blind Conjugated linoleic acid (3.4 g/d) or placebo (olive
oil) supplementation regime in combination with a modest hypocaloric diet of
–1250 kJ/d. After 1 year, no
significant difference in body weight or body fat regain was observed between
the treatments. The Conjugated linoleic acid group regained a mean 4.0 kg body
weight and 2 kg fat mass compared with a regain of 4 kg body
weight and 2.7 kg fat mass in the placebo group. No significant
differences in reported adverse effects or indexes of insulin resistance were
observed, but a significant increase in the number of leukocytes was observed
with Conjugated linoleic acid supplementation. A 3.4-g daily Conjugated linoleic
acid supplementation for 1 year
does not prevent weight or fat mass regain in a healthy obese population.
Lack of effect of dietary
conjugated linoleic acids naturally incorporated into butter on the lipid
profile and body composition of overweight and obese men
American Journal of Clinical Nutrition, Vol. 82, No. 2, 309-319,
August 2005
The researchers compared the effects on plasma lipoproteins and body
composition of the consumption of a modified butter naturally enriched with
Conjugated linoleic acid
(Conjugated linoleic acid-B: 4.22 g Conjugated linoleic acid/100 g butter fat) by the addition of sunflower oil to the
diet of dairy cows with the consumption of a control butter (CON-B) that was low
in Conjugated linoleic acid (0.38 g Conjugated linoleic acid/100 g butter fat). The study was a crossover design study
including an 8-wk washout period, 16 men were fed each of the 2 experimental
isoenergetic diets, providing 15% of energy as protein, 45% as carbohydrates,
and 40% as lipids, of which >60% was derived from experimental fats, for 4 wk.
Consumption of the Conjugated linoleic acid-B diet induced a significantly smaller reduction
in plasma total cholesterol and in the ratio of total to HDL cholesterol than
did consumption of the CON-B diet. Abdominal adipose tissue area showed no
difference in accumulation of either visceral or subcutaneous adipose tissue
after the 2 experimental diets. These results suggest that a 10-fold Conjugated
linoleic acid enrichment of butter fat does not induce beneficial metabolic effects in
overweight or obese men.
Conjugated linoleic acid
supplementation, insulin sensitivity, and lipoprotein metabolism in patients
with type 2 diabetes mellitus.
American Journal of Clinical Nutrition, Vol. 80, No. 4, 887-895,
October 2004
Some animal studies have suggested that conjugated linoleic acid
Conjugated linoleic acid supplementation may have therapeutic potential with respect
to insulin sensitivity and lipid metabolism, which are important cardiovascular
disease (CVD) risk factors associated with type 2 diabetes mellitus.
We investigated the effect of Conjugated linoleic acid supplementation on markers of glucose and
insulin metabolism, lipoprotein metabolism, and inflammatory markers of CVD in
subjects with type 2 diabetes. The study was a randomized, double-blind,
placebo-controlled trial. Thirty-two subjects with stable, diet-controlled type
2 diabetes received Conjugated linoleic acid (3.0 g/d; 50:50 blend of cis-9,trans-11
Conjugated linoleic acid and
trans-10,cis-12 Conjugated linoleic acid) or control for 8 wk. A 3-h 75-g oral-glucose-tolerance test
was performed, and fasting plasma lipid concentrations and inflammatory markers
were measured before and after the intervention. Conjugated linoleic acid supplementation
significantly increased fasting glucose concentrations and
reduced insulin sensitivity. Total HDL-cholesterol concentrations increased by 8%, which
was due to a significant increase in HDL2-cholesterol concentrations.
The ratio of LDL to HDL cholesterol was significantly reduced. Conjugated
linoleic acid
supplementation reduced fibrinogen concentrations but had no effect
on the inflammatory markers of CVD (C-reactive protein and interleukin 6).
Conjugated linoleic acid supplementation had an adverse
effect on insulin and glucose metabolism. Whereas Conjugated linoleic acid had positive effects on
HDL metabolism and fibrinogen, a therapeutic nutrient should not be associated
with potentially adverse effects on other clinical markers of type 2 diabetes.
Conjugated linoleic acid supplementation for 1 y reduces body
fat mass in healthy overweight humans
Background: Short-term trials showed that conjugated linoleic
acid Conjugated linoleic acid may reduce body fat mass (BFM) and increase lean
body mass (LBM), but the long-term effect of Conjugated linoleic acid was not examined.
Objective: The objective of the study was to ascertain the 1-y
effect of Conjugated linoleic acid on body composition and safety in healthy overweight
adults consuming an ad libitum diet. Design: Male and female
volunteers (n = 180) with body mass indexes (in kg/m2)
of 25–30 were included in a double-blind, placebo-controlled study.
Subjects were randomly assigned to 3 groups: Conjugated linoleic acid free fatty acid (FFA),
Conjugated linoleic acid triacylglycerol, or placebo (olive oil). Change in BFM, as
measured by dual-energy X-ray absorptiometry, was the primary
outcome. Secondary outcomes included the effects of Conjugated linoleic acid on LBM,
adverse events, and safety variables. Results: Mean
(± SD) BFM in the Conjugated linoleic acid triacylglycerol and Conjugated
linoleic acid FFA groups was 8.7 ±
9.1% and 6.9 ± 9.1%, respectively, lower than that in the placebo
group. Subjects receiving Conjugated linoleic acid FFA had 1.8 ± 4.3%
greater LBM than did subjects receiving placebo.
These changes were not associated with diet or exercise. LDL
increased in the Conjugated linoleic acid FFA group, HDL decreased in
the Conjugated linoleic acid triacylglycerol group, and lipoprotein(a)
increased in both Conjugated linoleic acid groups compared with month
0. Fasting blood glucose concentrations remained unchanged in all 3
groups. Glycated hemoglobin rose in all groups from month 0
concentrations, but there was no significant difference between
groups. Adverse events did not differ significantly between groups. Long-term supplementation with
Conjugated linoleic acid FFA or
Conjugated linoleic acid triacylglycerol reduces BFM in healthy overweight adults.
Conjugated linoleic acid
emails
Q. Why not eat more foods that have Conjugated linoleic acid rather than taking a
Conjugated linoleic acid
supplement?
A. A liter of full-fat milk
contains about 1 gram of Conjugated linoleic acid. This is not practical in terms of weight
loss.
Q. Would taking a
Conjugated linoleic acid
supplement along with hoodia help with weight loss more effectively?
A. It's hard to say, but the combination could be safe to try.
Q. Can a Conjugated
linoleic acid supplement be
taken along with Diet Rx?
A. Probably, but since Diet Rx works so well to reduce appetite,
there may not be a need to take a Conjugated linoleic acid supplement.
This Conjugated linoleic acid page was last updated in February 2008.