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6,7-Dihydroxybergamottin is a furanocoumarin that inhibits CYP3A4 and is found in grapefruit juice and Seville orange juice. A number of furanocoumarins isolated from grapefruit juice have been found to inhibit CYP3A4 activity in vitro including 6′,7′-epoxybergamottin, 6′,7′-dihydroxybergamottin and bergamottin.

As of 2010, no human studies with 6,7-Dihydroxybergamottin supplements have been published on Medline.